Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Vascular / VEGF signaling: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Retinal Vascular Microcirculation Rescue | 0.542 | neurodegeneration | Digital biomarkers and AI-driven early d |
| Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat | 0.505 | neurodegeneration | Perivascular spaces and glymphatic clear |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.623
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.605
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Pericyte-derived extracellular vesicles improve vascular barrier function in sep [PMID:39940043] | Zhang ZS, Yang A, Luo X, Zhou HN, Liu YY | Stem Cell Res Ther | 2025 | 1 |
| NETs induce ferroptosis of endothelial cells in LPS-ALI through SDC-1/HS and dow [PMID:38677244] | Fei Y, Huang X, Ning F, Qian T, Cui J, W | Biomed Pharmacother | 2024 | 1 |
| Irisin promotes fracture healing by improving osteogenesis and angiogenesis. [PMID:36196152] | Kan T, He Z, Du J, Xu M, Cui J, Han X, T | J Orthop Translat | 2022 | 1 |
| Protectin conjugates in tissue regeneration 1 restores lipopolysaccharide-induce [PMID:34217286] | Wang XY, Li XY, Wu CH, Hao Y, Fu PH, Mei | Respir Res | 2021 | 1 |
| STING activation reprograms tumor vasculatures and synergizes with VEGFR2 blocka [PMID:31343989] | Yang H, Lee WS, Kong SJ, Kim CG, Kim JH, | J Clin Invest | 2019 | 1 |
| The glycocalyx: a novel diagnostic and therapeutic target in sepsis. [PMID:30654825] | Uchimido R, Schmidt EP, Shapiro NI | Crit Care | 2019 | 1 |
| Astrocyte-Glioblastoma Stem Cell Interactions via Extracellular Vesicles Contrib [PMID:41712235] | Shirai Y, Tsuda M, Wang L, Oda Y, Sugizn | Pathology international | 2026 | 0 |
| Pathogenic Significance of Serum Syndecan-1 and Syndecan-4 in Psoriasis. [PMID:41839009] | Yıldırım MA, Korkmaz S, Çelik HHA, Büyük | Cutis | 2026 | 0 |
| CD138 expression in the endometrium associates with endometrial timing and infla [PMID:41858134] | Odendaal J, Fishwick K, Correia GDS, Lee | Human reproduction (Oxford, En | 2026 | 0 |
| [Multicenter prospective study on the diagnostic value of syndecan-1 for necroti [PMID:41914411] | Yin XY, Zhao ZH, Wang Y, Cai N, Chen S | Zhongguo dang dai er ke za zhi | 2026 | 0 |
| Association of Viraemic Phase Viral Load, Antibody Responses, and Immune Biomark [PMID:41891425] | Alagarasu K, Gurav YK, Pulinchani A, Bac | Journal of medical virology | 2026 | 0 |
| Effect of Normothermic Machine Perfusion on Glycocalyx Shedding During Liver Tra [PMID:41847595] | Mathis S, Putzer G, Gasteiger L, Staier | Transplant international : off | 2026 | 0 |
| Targeting hyperactive platelet-derived growth factor receptor-β signaling in T-c [PMID:37941480] | ["De Coninck S", "De Smedt R", "Linterma | Haematologica | 2024 | 0 |
| Ageing alters the lipid sensing process in the hypothalamus of Wistar rats. Effe [PMID:33544062] | ["Rodr\u00edguez M", "Pintado C", "Torri | Nutritional neuroscience | 2022 | 0 |
| Observation of Magic Number Clusters from Thermal Dissociation Molecular Dynamic [PMID:32286071] | ["Zhang J", "Bogdanov B", "Parkins A", " | The journal of physical chemis | 2020 | 0 |
| Reciprocal associations between depression, anxiety and work-related injury. [PMID:31685530] | ["Gerasimaviciute V", "B\u00fcltmann U", | Injury prevention : journal of | 2020 | 0 |
| Crenolanib-Derived Probes Suitable for Cell- and Tissue-Based Protein Profiling [PMID:30942519] | ["Chang Y", "Zhu D", "Guo H", "Yin X", " | Chembiochem : a European journ | 2019 | 0 |
| Layer-specific integration of locomotion and sensory information in mouse barrel [PMID:31197148] | ["Ayaz A", "St\u00e4uble A", "Hamada M", | Nature communications | 2019 | 0 |
| Syndecan-1 promotes lung fibrosis by regulating epithelial reprogramming through [PMID:31393853] | ["Parimon T", "Yao C", "Habiel D", "Ge L | JCI insight | 2019 | 0 |
| Somatic APP gene recombination in Alzheimer's disease and normal neurons. [PMID:30464338] | ["Lee M", "Siddoway B", "Kaeser G", "Seg | Nature | 2018 | 0 |